Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection

  title={Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection},
  author={Yi Liu and John P McNevin and Sarah E Holte and M Juliana McElrath and James I. Mullins},
  booktitle={PloS one},
Improved understanding of the dynamics of host immune responses and viral evolution is critical for effective HIV-1 vaccine design. We comprehensively analyzed Cytotoxic T-lymphocyte (CTL)-viral epitope dynamics in an antiretroviral therapy-naïve subject over the first four years of HIV-1 infection. We found that CTL responses developed sequentially and required constant antigenic stimulation for maintenance. CTL responses exerting strong selective pressure emerged early and led to rapid escape… CONTINUE READING
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