Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells.

@article{Lanzavecchia2000DynamicsOT,
  title={Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells.},
  author={Antonio Lanzavecchia and Federica Sallusto},
  journal={Science},
  year={2000},
  volume={290 5489},
  pages={92-7}
}
The immune response is initiated in organized lymphoid tissues where antigen-loaded dendritic cells (DCs) encounter antigen-specific T cells. DCs function as packets of information that must be decoded by the T cell before an appropriate immune response can be mounted. We discuss how the dynamics of DC-T cell encounter and the mechanism of T cell differentiation make the decoding of this information stochastic rather than determinate. This results in the generation of both terminally… CONTINUE READING
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