Dynamics of T cell activation threshold tuning.

  title={Dynamics of T cell activation threshold tuning.},
  author={Hugo A van den Berg and David A Rand},
  journal={Journal of theoretical biology},
  volume={228 3},
T lymphocytes are believed to alter their sensitivity to TCR stimulation by means of a tunable cellular activation threshold. We present two modelling examples which show that the concept of a tunable threshold can be made mechanistically plausible. The tunable threshold is treated as an emergent property of the dynamics of the T cell's signalling machinery. In addition, we discuss how the dynamic properties of activation threshold tuning can be determined experimentally with the aid of these… CONTINUE READING


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