Dynamics of Simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues.

@article{Veazey2003DynamicsOS,
  title={Dynamics of Simian immunodeficiency virus-specific cytotoxic T-cell responses in tissues.},
  author={Ronald S Veazey and Jeffrey D Lifson and Joern E Schmitz and Marcelo J. Kuroda and Michael J. Piatak and Ivona Pandrea and Jeannette Purcell and Rudolf Bohm and James Blanchard and Kenneth Williams and Andrew A Lackner},
  journal={Journal of medical primatology},
  year={2003},
  volume={32 4-5},
  pages={194-200}
}
Although the dynamics of human immunodeficiency virus and Simian immunodeficiency virus (SIV)-specific cytotoxic T cells (CTLs) have been well documented in the blood, little is known regarding CTL development in other tissues. In this study, seven Mamu-A*01+ macaques were inoculated with SIVmac. Two macaques were killed at 21 days of infection, and SIV gag p11C tetramer responses were measured in the blood, axillary and mesenteric lymph nodes, spleen, bone marrow, and thymus. Three with… CONTINUE READING
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