Dynamics of SNARE Assembly and Disassembly during Sperm Acrosomal Exocytosis

  title={Dynamics of SNARE Assembly and Disassembly during Sperm Acrosomal Exocytosis},
  author={Gerardo A. De Blas and Carlos M Roggero and Claudia N Tomes and Luis S. Mayorga},
  journal={PLoS Biology},
  pages={581 - 632}
The dynamics of SNARE assembly and disassembly during membrane recognition and fusion is a central issue in intracellular trafficking and regulated secretion. Exocytosis of sperm's single vesicle--the acrosome--is a synchronized, all-or-nothing process that happens only once in the life of the cell and depends on activation of both the GTP-binding protein Rab3 and of neurotoxin-sensitive SNAREs. These characteristics make acrosomal exocytosis a unique mammalian model for the study of the… CONTINUE READING


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aSNAP and NSF are required in a priming step during the human sperm acrosome reaction

  • CN Tomes, GA De Blas, MA Michaut, EV Farre, O Cherhitin
  • Mol Hum Reprod
  • 2005
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