Dynamics of Polymorphism in a Malaria Vaccine Antigen at a Vaccine-Testing Site in Mali

  title={Dynamics of Polymorphism in a Malaria Vaccine Antigen at a Vaccine-Testing Site in Mali},
  author={Shannon L. Takala and D. Coulibaly and Mahamadou A Thera and Alassane Dicko and David L. Smith and Ando B. Guindo and Abdoulaye Kassoum Kone and Karim Traore and A. D. Ouattara and Abdoulaye A. Djimd{\'e} and Paul S Sehdev and Kirsten E. Lyke and Dapa Aly Diallo and Ogobara K. Doumbo and Christopher V. Plowe},
  journal={PLoS Medicine},
  pages={670 - 672}
BACKGROUND Malaria vaccines based on the 19-kDa region of merozoite surface protein 1 (MSP-1(19)) derived from the 3D7 strain of Plasmodium falciparum are being tested in clinical trials in Africa. Knowledge of the distribution and natural dynamics of vaccine antigen polymorphisms in populations in which malaria vaccines will be tested will guide vaccine design and permit distinction between natural fluctuations in genetic diversity and vaccine-induced selection. METHODS AND FINDINGS Using… CONTINUE READING
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, adjuvanted with AS 02 A , in adults in western Kenya

  • MA Thera, OK Doumbo, D Coulibaly, DA Diallo, I Sagara
  • 2006

Phase I safety and immunogenicity trial of FMP 1 / AS 02 A , a Plasmodium falciparum MSP - 1 asexual blood stage

  • CF Ockenhouse, E Angov, KE Kester, C Diggs, L Soisson
  • 2006

efficacy trials in Bandiagara , Mali

  • SL Takala, DL Smith, OC Stine, D Coulibaly, MA Thera
  • 2006

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