Dynamics of Polymorphism in a Malaria Vaccine Antigen at a Vaccine-Testing Site in Mali

Abstract

BACKGROUND Malaria vaccines based on the 19-kDa region of merozoite surface protein 1 (MSP-1(19)) derived from the 3D7 strain of Plasmodium falciparum are being tested in clinical trials in Africa. Knowledge of the distribution and natural dynamics of vaccine antigen polymorphisms in populations in which malaria vaccines will be tested will guide vaccine… (More)

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@article{Takala2007DynamicsOP, title={Dynamics of Polymorphism in a Malaria Vaccine Antigen at a Vaccine-Testing Site in Mali}, author={Shannon L. Takala and Drissa Coulibaly and Mahamadou A Thera and A lassane Dicko and David L. Smith and Ando B. Guindo and Abdoulaye Kassoum Kone and Karim Traore and Amed Ouattara and Abdoulaye A. Djimd{\'e} and P. Sehdev and Kirsten E. Lyke and Dapa Aly Diallo and Ogobara K. Doumbo and Christopher V. Plowe}, journal={PLoS Medicine}, year={2007}, volume={4}, pages={670 - 672} }