Dynamics of Lamin-A Processing Following Precursor Accumulation

Abstract

Lamin A (LaA) is a component of the nuclear lamina, an intermediate filament meshwork that underlies the inner nuclear membrane (INM) of the nuclear envelope (NE). Newly synthesized prelamin A (PreA) undergoes extensive processing involving C-terminal farnesylation followed by proteolysis yielding non-farnesylated mature lamin A. Different inhibitors of… (More)
DOI: 10.1371/journal.pone.0010874

Topics

6 Figures and Tables

Slides referencing similar topics