Dynamics of Ionic Shifts in Cortical Spreading Depression.

  title={Dynamics of Ionic Shifts in Cortical Spreading Depression.},
  author={Rune Enger and Wannan Tang and Gry Fluge Vindedal and Vidar Jensen and P Johannes Helm and Rolf Sprengel and Loren L. Looger and Erlend A. Nagelhus},
  journal={Cerebral cortex},
  volume={25 11},
Cortical spreading depression is a slowly propagating wave of near-complete depolarization of brain cells followed by temporary suppression of neuronal activity. Accumulating evidence indicates that cortical spreading depression underlies the migraine aura and that similar waves promote tissue damage in stroke, trauma, and hemorrhage. Cortical spreading depression is characterized by neuronal swelling, profound elevation of extracellular potassium and glutamate, multiphasic blood flow changes… CONTINUE READING