Dynamics of HIV neutralization by a microbicide formulation layer: biophysical fundamentals and transport theory.

@article{Geonnotti2006DynamicsOH,
  title={Dynamics of HIV neutralization by a microbicide formulation layer: biophysical fundamentals and transport theory.},
  author={Anthony R. Geonnotti and David F. Katz},
  journal={Biophysical journal},
  year={2006},
  volume={91 6},
  pages={2121-30}
}
Topical microbicides are an emerging HIV/AIDS prevention modality. Microbicide biofunctionality requires creation of a chemical-physical barrier against HIV transmission. Barrier effectiveness derives from properties of the active compound and its delivery system, but little is known about how these properties translate into microbicide functionality. We developed a mathematical model simulating biologically relevant transport and HIV-neutralization processes occurring when semen-borne virus… CONTINUE READING

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