Dynamics of HIV Latency and Reactivation in a Primary CD4+ T Cell Model

  title={Dynamics of HIV Latency and Reactivation in a Primary CD4+ T Cell Model},
  author={Pejman Mohammadi and Julia di Iulio and Miguel Mu{\~n}oz and Raquel Mart{\'i}nez and Istv{\'a}n Bartha and Matthias Cavassini and Christian Wandall Thorball and Jacques Fellay and Niko Beerenwinkel and Angela Ciuffi and Amalio Telenti},
  booktitle={PLoS pathogens},
HIV latency is a major obstacle to curing infection. Current strategies to eradicate HIV aim at increasing transcription of the latent provirus. In the present study we observed that latently infected CD4+ T cells from HIV-infected individuals failed to produce viral particles upon ex vivo exposure to SAHA (vorinostat), despite effective inhibition of histone deacetylases. To identify steps that were not susceptible to the action of SAHA or other latency reverting agents, we used a primary CD4… CONTINUE READING
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