Dynamics of Gut-Brain Communication Underlying Hunger

@article{Beutler2017DynamicsOG,
  title={Dynamics of Gut-Brain Communication Underlying Hunger},
  author={Lisa R. Beutler and Yiming Chen and Jamie S. Ahn and Yen-Chu Lin and Rachel A. Essner and Zachary A Knight},
  journal={Neuron},
  year={2017},
  volume={96},
  pages={461-475.e5}
}
Communication between the gut and brain is critical for homeostasis, but how this communication is represented in the dynamics of feeding circuits is unknown. Here we describe nutritional regulation of key neurons that control hunger in vivo. We show that intragastric nutrient infusion rapidly and durably inhibits hunger-promoting AgRP neurons in awake, behaving mice. This inhibition is proportional to the number of calories infused but surprisingly independent of macronutrient identity or… CONTINUE READING
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