Dynamics of GPI-anchored proteins on the surface of living cells.

  title={Dynamics of GPI-anchored proteins on the surface of living cells.},
  author={Anja G Nohe and Eleonora Keating and Marc Fivaz and F Gisou van der Goot and Nils O. Petersen},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  volume={2 1},
Rather than being distributed homogeneously on the cell surface, proteins are probably aggregated in clusters or in specific domains. Some of these domains (lipid rafts) have lipid compositions, which differ from their surrounding membrane. They have been implicated in cell signaling, cell adhesion, and cholesterol homeostasis. Estimates of their size vary from 40 to 350 nm in diameter depending on the study and cell type used. Rafts are enriched in glycosphingolipids and cholesterol and appear… CONTINUE READING
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