Dynamics of EGFR mutations in plasma recapitulates the clinical response to EGFR-TKIs in NSCLC patients

@inproceedings{Xiong2017DynamicsOE,
  title={Dynamics of EGFR mutations in plasma recapitulates the clinical response to EGFR-TKIs in NSCLC patients},
  author={Liwen Xiong and Shaohua Cui and Jingyan Ding and Yun Sun and Longfu Zhang and Yizhuo Zhao and Aiqin Gu and Tianqing Chu and Hong Shen Wang and Hua Zhong and Xin Ye and Yi Gu and Xin Zhang and Min Hu and Liyan Jiang},
  booktitle={Oncotarget},
  year={2017}
}
OBJECTIVES Genomic profiling using plasma cell-free DNA (cfDNA) represents a non-invasive alternative to tumor re-biopsy, which is challenging in clinical practice. The feasibility of dynamically monitoring epidermal growth factor receptor (EGFR) mutation status using serial plasma samples from non-small cell lung cancer (NSCLC) patients treated by tyrosine kinase inhibitors (TKIs) and its application in tracking clinical response and detection of resistance were investigated. PATIENTS AND… CONTINUE READING
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