Dynamics of EGFR mutations in plasma recapitulates the clinical response to EGFR-TKIs in NSCLC patients

@inproceedings{Xiong2017DynamicsOE,
  title={Dynamics of EGFR mutations in plasma recapitulates the clinical response to EGFR-TKIs in NSCLC patients},
  author={Liwen Xiong and Shaohua Cui and Jingyan Ding and Yun Sun and Longfu Zhang and Yizhuo Zhao and Aiqin Gu and Tianqing Chu and H Wang and Hua Zhong and Xin Ye and Yi Gu and X Zhang and Min Hu and Liyan Jiang},
  booktitle={Oncotarget},
  year={2017}
}
OBJECTIVES Genomic profiling using plasma cell-free DNA (cfDNA) represents a non-invasive alternative to tumor re-biopsy, which is challenging in clinical practice. The feasibility of dynamically monitoring epidermal growth factor receptor (EGFR) mutation status using serial plasma samples from non-small cell lung cancer (NSCLC) patients treated by tyrosine kinase inhibitors (TKIs) and its application in tracking clinical response and detection of resistance were investigated. PATIENTS AND… CONTINUE READING