Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation

@inproceedings{Schermelleh2007DynamicsOD,
  title={Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation},
  author={Lothar Schermelleh and Andrea Haemmer and Fabio Spada and Nicole R{\"o}sing and Daniela Meilinger and Ulrich Rothbauer and M. Cristina Cardoso and Heinrich Leonhardt},
  booktitle={Nucleic acids research},
  year={2007}
}
Postreplicative maintenance of genomic methylation patterns was proposed to depend largely on the binding of DNA methyltransferase 1 (Dnmt1) to PCNA, a core component of the replication machinery. We investigated how the slow and discontinuous DNA methylation could be mechanistically linked with fast and processive DNA replication. Using photobleaching and quantitative live cell imaging we show that Dnmt1 binding to PCNA is highly dynamic. Activity measurements of a PCNA-binding-deficient… CONTINUE READING

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