Dynamics of DNA Replication in Mammalian Somatic Cells Nucleotide Pool Modulates Origin Choice and Interorigin Spacing

@article{Anglana2003DynamicsOD,
  title={Dynamics of DNA Replication in Mammalian Somatic Cells Nucleotide Pool Modulates Origin Choice and Interorigin Spacing},
  author={Mauro Anglana and Françoise Apiou and Aaron Bensimon and Michelle Debatisse},
  journal={Cell},
  year={2003},
  volume={114},
  pages={385-394}
}
Selection of active origins and regulation of interorigin spacing are poorly understood in mammalian cells. Using tricolor analysis of combed DNA molecules, we studied an amplified locus containing the known origin, oriGNAI3. We visualized replication firing events at this and other discrete regions and established a strict correlation between AT richness and initiation sites. We found that oriGNAI3 is the prominent origin of the domain, the firing of which correlates with silencing of… CONTINUE READING

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