Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations

@article{Tavassoly2013DynamicsOC,
  title={Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations},
  author={Iman Tavassoly},
  journal={Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells},
  year={2013}
}
  • I. Tavassoly
  • Published 21 August 2013
  • Biology
  • Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells
View on Springer
21 Citations
Background Citations
6
Methods Citations
5

21 Citations

Citation Type

Citation Type

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The analysis of publicly available datasets of genes, genomic determinants, and levels of obesity-related hormones in the blood revealed tissue- and organ-specific metabolic impairments and potential new drug targets, organized into a tissue/organ-based subcellular-function atlas for human obesity.
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Fate decisions mediated by crosstalk of autophagy and apoptosis in mammalian cells
TLDR
A computational model for cell fate decisions based on intertwined dynamics with autophagy and apoptosis involving Ca 2+ , mTOR, and both ER stress and nutritional stress is presented.
Inhibition of Brain Epidermal Growth Factor Receptor Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries
TLDR
It is concluded that EGFR inhibitors can be beneficial in treatment of neurodegenerative diseases and spinal cord injuries and carry their therapeutic potentials through induction of autophagy and attenuation of reactive astrocytes.
ZEA-induced autophagy in TM4 cells was mediated by the release of Ca2+ activates CaMKKβ-AMPK signaling pathway in the endoplasmic reticulum.
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