Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations
@article{Tavassoly2013DynamicsOC, title={Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations}, author={Iman Tavassoly}, journal={Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells}, year={2013} }
21 Citations
A Systems Biology Roadmap to Decode mTOR Control System in Cancer
- BiologyInterdisciplinary Sciences: Computational Life Sciences
- 2019
A systems biology roadmap to study mTOR control system is proposed, which introduces the theoretical and experimental modalities to decode temporal and dynamical characteristics of mTOR signaling in cancer.
Decoding clinical biomarker space of COVID-19: Exploring matrix factorization-based feature selection methods
- Computer ScienceComputers in Biology and Medicine
- 2022
Decoding Clinical Biomarker Space of COVID-19: Exploring Matrix Factorization-based Feature Selection Methods
- Computer SciencemedRxiv
- 2021
A machine learning approach is presented to find a group of clinical indicators from the blood tests of a set of COVID-19 patients that are predictive of poor prognosis and morbidity and reveals that Arterial Blood Gas O2 Saturation and C-Reactive Protein are the most important clinical biomarkers determining thepoor prognosis in these patients.
High Dimensionality Reduction by Matrix Factorization for Systems Pharmacology
- Computer SciencebioRxiv
- 2021
The Matrix Factorization is utilized as a modality for high dimensionality reduction in systems pharmacology and three novel feature selection methods are proposed using the mathematical conception of a basis, capable of reducing the feature spaces and finding predictive features in terms of phenotype determination.
Quercetin as a Novel Therapeutic Approach for Lymphoma
- Medicine, BiologyOxidative medicine and cellular longevity
- 2021
It seems that more clinical studies should introduce quercetin as a therapeutic, alone or in combination with other chemotherapy agents, and highlighted the potential therapeutic effects of quercETin in various types of lymphoma.
A tissue- and organ-based cell biological atlas of obesity-related human genes and cellular pathways
- Biology, MedicinebioRxiv
- 2020
The analysis of publicly available datasets of genes, genomic determinants, and levels of obesity-related hormones in the blood revealed tissue- and organ-specific metabolic impairments and potential new drug targets, organized into a tissue/organ-based subcellular-function atlas for human obesity.
Computational modeling of the effects of autophagy on amyloid-β peptide levels
- BiologyTheoretical Biology and Medical Modelling
- 2020
A mathematical model for autophagy with respect to Aβ kinetics predicts that modulations of different steps of the Autophagy pathway have significant step-specific and combined effects on the Aβ levels and thus suggests therapeutic and preventive implications of autophile in AD.
Fate decisions mediated by crosstalk of autophagy and apoptosis in mammalian cells
- BiologyJournal of biological physics
- 2020
A computational model for cell fate decisions based on intertwined dynamics with autophagy and apoptosis involving Ca 2+ , mTOR, and both ER stress and nutritional stress is presented.
Inhibition of Brain Epidermal Growth Factor Receptor Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries
- Biology, MedicineMolecular Pharmacology
- 2020
It is concluded that EGFR inhibitors can be beneficial in treatment of neurodegenerative diseases and spinal cord injuries and carry their therapeutic potentials through induction of autophagy and attenuation of reactive astrocytes.
ZEA-induced autophagy in TM4 cells was mediated by the release of Ca2+ activates CaMKKβ-AMPK signaling pathway in the endoplasmic reticulum.
- Chemistry, BiologyToxicology letters
- 2020