Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability.

Abstract

The cystic fibrosis transmembrane conductance regulator (CFTR) requires dynamic fluctuations between states in its gating cycle for proper channel function, including changes in the interactions between the nucleotide-binding domains (NBDs) and between the intracellular domain (ICD) coupling helices and NBDs. Such motions are also linked with fluctuating… (More)
DOI: 10.1101/cshperspect.a009522

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