Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle

@article{Kafri2013DynamicsEF,
  title={Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle},
  author={Ran Kafri and Jason Levy and Miriam Bracha Ginzberg and Seungeun Oh and Galit Lahav and Marc W Kirschner},
  journal={Nature},
  year={2013},
  volume={494},
  pages={480-483}
}
Biologists have long been concerned about what constrains variation in cell size, but progress in this field has been slow and stymied by experimental limitations. Here we describe a new method, ergodic rate analysis (ERA), that uses single-cell measurements of fixed steady-state populations to accurately infer the rates of molecular events, including rates of cell growth. ERA exploits the fact that the number of cells in a particular state is related to the average transit time through that… CONTINUE READING

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