Dynamics between Cancer Cell Subpopulations Reveals a Model Coordinating with Both Hierarchical and Stochastic Concepts

@inproceedings{Wang2014DynamicsBC,
  title={Dynamics between Cancer Cell Subpopulations Reveals a Model Coordinating with Both Hierarchical and Stochastic Concepts},
  author={Weikang Wang and Y C Quan and Qibin Fu and Yu Liu and Ying Liang and Jingwen Wu and Gen Yang and Chunxiong Luo and Qi Ouyang and Yugang Wang},
  booktitle={PloS one},
  year={2014}
}
Tumors are often heterogeneous in which tumor cells of different phenotypes have distinct properties. For scientific and clinical interests, it is of fundamental importance to understand their properties and the dynamic variations among different phenotypes, specifically under radio- and/or chemo-therapy. Currently there are two controversial models describing tumor heterogeneity, the cancer stem cell (CSC) model and the stochastic model. To clarify the controversy, we measured probabilities of… CONTINUE READING
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