Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen.

@article{Jellison2007DynamicsAM,
  title={Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen.},
  author={Evan R. Jellison and Heath M. Guay and Eva Szomolanyi-Tsuda and Raymond M. Welsh},
  journal={European journal of immunology},
  year={2007},
  volume={37 1},
  pages={119-28}
}
Hypergammaglobulinemia and production of autoantibodies occur during many viral infections, and studies have suggested that viral antigen-presenting B cells may become polyclonally activated by CD4 T cells in vivo in the absence of viral engagement of the BCR. However, we have reported that CD4 cells in lymphocytic choriomengitis virus (LCMV)-infected mice kill adoptively transferred B cells coated with LCMV class II peptides. We report here that most of the surviving naïve B cells presenting… CONTINUE READING