Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice.

@article{Osmond1992DynamicsAL,
  title={Dynamics and localization of early B-lymphocyte precursor cells (pro-B cells) in the bone marrow of scid mice.},
  author={Dennis G. Osmond and Hei Jung Kim and Raffi Manoukian and Rebecca A. Phillips and S A Rico-Vargas and Kimberly Jacobsen},
  journal={Blood},
  year={1992},
  volume={79 7},
  pages={
          1695-703
        }
}
Mice homozygous for the scid (severe combined immunodeficiency) mutation are generally unable to produce B lymphocytes, a condition attributed to defective rearrangement of immunoglobulin genes in precursor B cells. Some early B-lineage cells are present in the bone marrow (BM), however. In scid mice, we defined three subsets of early progenitor B cells lacking mu heavy chains (pro-B cells) based on the expression of terminal deoxynucleotidyl transferase (TdT) and B220 glycoprotein: (a) early… CONTINUE READING

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