Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry.

Abstract

Receptors for retinoic acid act as ligand activated transcription factors. The three-dimensional structure of the retinoid X receptor (RXR) ligand binding domain has been determined, but little information is available concerning the properties of the protein in solution. Hydrogen/deuterium exchange followed by electrospray ionization mass spectrometry was… (More)

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@article{Yan2004DynamicsAL, title={Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry.}, author={Xuguang Yan and David J. Broderick and Mark E Leid and Michael I. Schimerlik and Max L Deinzer}, journal={Biochemistry}, year={2004}, volume={43 4}, pages={909-17} }