Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides.

  title={Dynamics and energetics of the base flipping conformation studied with base pair-mimic nucleosides.},
  author={Shu-Ichi Nakano and Hirohito Oka and Yuuki Uotani and Kazuya Uenishi and Masayuki Fujii and Naoki Sugimoto},
  volume={48 47},
A base flipping conformation is found in many biological processes, including DNA repair and DNA and RNA modification processes. To investigate the dynamics and energetics of this unusual conformation in a double helix, base flipping induced by the base pair analogues of deoxyadenosine and deoxycytidine derivatives tethering a phenyl or naphthyl group was investigated. DNA strands bearing the base pair analogues stabilized the base flipping conformation of a complementary RNA, resulting in a… Expand
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