Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma

@inproceedings{Zhong2012DynamicallyEM,
  title={Dynamically expressed microRNA-15b modulates the activities of CD8+ T lymphocytes in mice with Lewis lung carcinoma},
  author={Guocheng Zhong and Xiao-ming Cheng and Haixia Long and Luhang He and Wei Qi and Tong Xiang and Zhongquan Zhao and Bo Zhu},
  booktitle={Journal of Translational Medicine},
  year={2012}
}
CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill tumor cells but come into apoptosis in a certain period and the latter is static with the ability of self-renewal. Previous studies showed that microRNAs (miRNA) played critical roles in regulating adaptive immunity. This study aimed to identify the different expression of miRNAs between Te and… CONTINUE READING

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