Dynamically acetylated histone association with transcriptionally active and competent genes in the avian adult beta-globin gene domain.

@article{Spencer2001DynamicallyAH,
  title={Dynamically acetylated histone association with transcriptionally active and competent genes in the avian adult beta-globin gene domain.},
  author={Virginia A. Spencer and James R. Davie},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 37},
  pages={34810-5}
}
In chicken immature erythrocytes, class 1 acetylated histones are rapidly tri- and tetra-acetylated and rapidly deacetylated. Class 2 acetylated H3 and H4 are rapidly acetylated to mono- and di-acetylated isoforms and slowly deacetylated. Our previous studies suggested that class 1 acetylated histones were primarily associated with transcriptionally active DNA (beta(A)-globin) but not competent DNA (epsilon-globin). Chromatin salt solubility (chromatin fiber oligomerization) is directly… CONTINUE READING