Dynamical systems approach to endothelial heterogeneity.

  title={Dynamical systems approach to endothelial heterogeneity.},
  author={Erzs{\'e}bet Ravasz Regan and William C. Aird},
  journal={Circulation research},
  volume={111 1},
Endothelial cells display remarkable phenotypic heterogeneity. An important goal is to elucidate the scope and mechanisms of endothelial heterogeneity and to use this information to develop vascular bed-specific therapies. We reexamine our current understanding of the molecular basis of endothelial heterogeneity. We introduce multistability as a new explanatory framework in vascular biology. We draw on the field of nonlinear dynamics to propose a dynamical systems framework for modeling… CONTINUE READING
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