Dynamical modeling of uncertain interaction-based genomic networks

  title={Dynamical modeling of uncertain interaction-based genomic networks},
  author={Daniel N. Mohsenizadeh and Jianping Hua and Michael L. Bittner and Edward R. Dougherty},
  booktitle={BMC Bioinformatics},
Most dynamical models for genomic networks are built upon two current methodologies, one process-based and the other based on Boolean-type networks. Both are problematic when it comes to experimental design purposes in the laboratory. The first approach requires a comprehensive knowledge of the parameters involved in all biological processes a priori, whereas the results from the second method may not have a biological correspondence and thus cannot be tested in the laboratory. Moreover, the… CONTINUE READING
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