Dynamical Scaling and Phase Coexistence in Topologically-Constrained DNA Melting

@article{Fosado2017DynamicalSA,
  title={Dynamical Scaling and Phase Coexistence in Topologically-Constrained DNA Melting},
  author={Yair A. G. Fosado and Davide Michieletto and Davide Marenduzzo},
  journal={bioRxiv},
  year={2017}
}
There is a long-standing experimental observation that the melting of topologically constrained DNA, such as circular-closed plasmids, is less abrupt than that of linear molecules. This finding points to an important role of topology in the physics of DNA denaturation, which is however poorly understood. Here, we shed light on this issue by combining large-scale Brownian Dynamics simulations with an analytically solvable phenomenological Landau mean field theory. We find that the competition… 
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