Dynamic value assessments in oncology supported by the PACE Continuous Innovation Indicators.

@article{Paddock2017DynamicVA,
  title={Dynamic value assessments in oncology supported by the PACE Continuous Innovation Indicators.},
  author={Silvia Paddock and Clifford S. Goodman and Scott H Shortenhaus and David L Grainger and Jacqueline Zummo and Samuel Thomas},
  journal={Future oncology},
  year={2017},
  volume={13 25},
  pages={
          2253-2264
        }
}
AIM Several recently developed frameworks aim to assess the value of cancer treatments, but the most appropriate metrics remain uncertain. METHODS We use data from the Patient Access to Cancer care Excellence Continuous Innovation Indicators to examine the relationship between hazard ratios (HRs) from clinical trials and dynamic therapeutic value accumulating over time. RESULTS Our analysis shows that HRs from initial clinical trials poorly predict the eventual therapeutic value of cancer… CONTINUE READING
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