Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.

  title={Dynamic up-regulation of prodynorphin transcription in temporal lobe epilepsy.},
  author={Susanne Pirker and Elisabeth Gasser and Thomas Czech and Christoph Baumgartner and Elisabeth Schuh and Martha Feucht and Klaus Novak and Fritz Zimprich and G{\"u}nther Sperk},
  volume={19 11},
Dynorphin neuropeptides are believed to act as endogenous anticonvulsants, though direct evidence for such a role in humans is sparse. We now report pronounced increases of prodynorphin mRNA expression in the dentate gyrus of patients with temporal lobe epilepsy in comparison to controls. We detected a conspicuously right skewed, bimodal distribution of mRNA levels among patients, suggestive of a dynamic up-regulation of prodynorphin expression in epilepsy. Highest transcript levels were seen… CONTINUE READING

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