Dynamic transmurality: Cardiac Optical Mapping reveals Waves Travel across Transmural Ablation Lines

@article{Simonotto2007DynamicTC,
  title={Dynamic transmurality: Cardiac Optical Mapping reveals Waves Travel across Transmural Ablation Lines},
  author={Jennifer D. Simonotto and Michael D. Furman and William L. Ditto and Abraham Miliotis and Mark L. Spano and Thomas M. Beaver},
  journal={Int. J. Bifurc. Chaos},
  year={2007},
  volume={17},
  pages={3229-3234}
}
Cardiac ablation is increasingly used to interdict the complex propagation of excitatory waves during atrial fibrillation. While such procedures are useful, they can often fail. Here we use fluorescence imaging to observe the electrical activity of an ablated porcine heart. We find that, while ablation lines do attenuate cardiac waves, the attenuation is incomplete. A remnant of the incident wave survives passage through the ablation barrier, albeit as a subthreshold signal. More importantly… 
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References

SHOWING 1-10 OF 21 REFERENCES

Spatiotemporal evolution of ventricular fibrillation

High spatial and temporal resolution mapping of optical transmembrane potentials can easily detect transiently erupting rotors during the early phase of ventricular fibrillation, characterized by a relatively high spatiotemporal cross-correlation.

Atricure bipolar radiofrequency clamp for intraoperative ablation of atrial fibrillation.

Catheter Ablation for Paroxysmal Atrial Fibrillation: Segmental Pulmonary Vein Ostial Ablation Versus Left Atrial Ablation

In patients undergoing catheter ablation for PAF, LACA to encircle the PVs is more effective than SOCA, and the only complication was left atrial flutter in a patient who underwent LACA.

Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.

The pulmonary veins are an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation and these foci respond to treatment with radio-frequency ablation.

New ideas about atrial fibrillation 50 years on

The prevailing model of atrial fibrillation involved multiple simultaneous re-entrant waves, but in light of new discoveries this hypothesis is now undergoing re-evaluation.

Using recurrence quantification analysis determinism for noise removal in cardiac optical mapping

The method illustrates an improved process for selecting filtering parameters and how using measured signal-to-noise ratio alone can lead to improper parameter selection.

Successful performance of Cox-Maze procedure on beating heart using bipolar radiofrequency ablation: a feasibility study in animals.

Voltage-sensitive dyes for monitoring multineuronal activity in the intact central nervous system

Both general characteristics of optical measurements (sources of noise) as well as more methodological aspects related to voltage-sensitive dye measurements from the nervous system are discussed.

Voltage-sensitive dye mapping in Langendorff-perfused rat hearts.

The time-dependent effects of the dye on the rat heart were characterized and include a transient vasodilation at the onset of dye perfusion and a long-lasting prolongation of the PQ interval of the electrocardiogram, frequently resulting in brief episodes of atrioventricular block.

The Standard Maze-III Procedure

The original Maze procedure (Maze-I) was introduced clinically in September 1987 but was modified to the Maze-II procedure in the next 15 patients, which proved to be extremely difficult to perform technically because of the frequent necessity for transection of the SVC.