Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping

@article{Dutrow2008DynamicTO,
  title={Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping},
  author={Natalie Dutrow and David A. Nix and Derick G. Holt and Brett Milash and Brian K. Dalley and E M Westbroek and Timothy J Parnell and Bradley R. Cairns},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={977-986}
}
We have determined the high-resolution strand-specific transcriptome of the fission yeast S. pombe under multiple growth conditions using a novel RNA-DNA hybridization mapping (HybMap) technique. HybMap uses an antibody against an RNA-DNA hybrid to detect RNA molecules hybridized to a high-density DNA oligonucleotide tiling microarray. HybMap showed exceptional dynamic range and reproducibility, and allowed us to identify strand-specific coding, noncoding and structural RNAs, as well as… CONTINUE READING
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