Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture

@article{Bruce2007DynamicTP,
  title={Dynamic transcription programs during ES cell differentiation towards mesoderm in serum versus serum-freeBMP4 culture},
  author={Stephen J Bruce and Brooke B A Gardiner and Les J Burke and M. Milena Gongora and Sean M. Grimmond and Andrew C. Perkins},
  journal={BMC Genomics},
  year={2007},
  volume={8},
  pages={365 - 365}
}
Expression profiling of embryonic stem (ES) cell differentiation in the presence of serum has been performed previously. It remains unclear if transcriptional activation is dependent on complex growth factor mixtures in serum or whether this process is intrinsic to ES cells once the stem cell program has been inactivated. The aims of this study were to determine the transcriptional programs associated with the stem cell state and to characterize mesoderm differentiation between serum and serum… CONTINUE READING

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