Dynamic trans-Acting Factor Colocalization in Human Cells

  title={Dynamic trans-Acting Factor Colocalization in Human Cells},
  author={Dan Xie and Alan P. Boyle and Linfeng Wu and Jie Zhai and Trupti Kawli and Michael Snyder},
Different trans-acting factors (TFs) collaborate and act in concert at distinct loci to perform accurate regulation of their target genes. To date, the cobinding of TF pairs has been investigated in a limited context both in terms of the number of factors within a cell type and across cell types and the extent of combinatorial colocalizations. Here, we use an approach to analyze TF colocalization within a cell type and across multiple cell lines at an unprecedented level. We extend this… CONTINUE READING
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