Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury.

@article{Lee2011DynamicTA,
  title={Dynamic temporal and spatial regulation of mu opioid receptor expression in primary afferent neurons following spinal nerve injury.},
  author={Chun-Yi Lee and Federico M. Perez and Wei Wang and Xiaowei Guan and Xiuli Zhao and Janet L. Fisher and Yun Guan and Sarah M. Sweitzer and Srinivasa N Raja and Yuan-Xiang Tao},
  journal={European journal of pain},
  year={2011},
  volume={15 7},
  pages={669-75}
}
Despite using prescribed pain medications, patients with neuropathic pain continue to experience moderate to severe pain. There is a growing recognition of a potent peripheral opioid analgesia in models of inflammatory and neuropathic pain. The goal of this study was to characterize the temporal and spatial expression of mu opioid receptor (mOR) mRNA and protein in primary afferent neurons in a rat L5 spinal nerve ligation model of persistent neuropathic pain. Bilateral L4 and L5 dorsal root… CONTINUE READING
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Neuropathic pain: quality-of-life impact, costs and cost effectiveness of therapy

  • AB O’Connor
  • Pharmacoeconomics
  • 2009
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