Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.

@article{Tait2007DynamicSI,
  title={Dynamic stromal-epithelial interactions during progression of MCF10DCIS.com xenografts.},
  author={Larry R Tait and Robert J. Pauley and Steven J. Santner and Gloria H. Heppner and Henry H Heng and Janusz Rak and F. Roy Miller},
  journal={International journal of cancer},
  year={2007},
  volume={120 10},
  pages={2127-34}
}
MCF10DCIS.com cells form comedo type ductal carcinoma in situ in immune-deficient mice before forming invasive ductal carcinoma. As the lesions mature, both stromal and epithelial cells undergo phenotypic changes detected by immunohistochemistry. Myofibroblasts are present before the formation of carcinoma in situ and after development of invasive carcinoma. MCF10DCIS. com lesions develop a myoepithelial layer prior to exhibiting a basement membrane surrounding the ductal mass. TGFbeta1 is… CONTINUE READING