Dynamic stretch correlates to both morphological abnormalities and electrophysiological impairment in a model of traumatic axonal injury.

@article{Bain2001DynamicSC,
  title={Dynamic stretch correlates to both morphological abnormalities and electrophysiological impairment in a model of traumatic axonal injury.},
  author={Allison C. Bain and Ramesh Raghupathi and David F. Meaney},
  journal={Journal of neurotrauma},
  year={2001},
  volume={18 5},
  pages={
          499-511
        }
}
In this investigation, the relationships between stretch and both morphological and electrophysiological signs of axonal injury were examined in the guinea pig optic nerve stretch model. Additionally, the relationship between axonal morphology and electrophysiological impairment was assessed. Axonal injury was produced in vivo by elongating the guinea pig optic nerve between 0 and 8 mm (Ntotal = 70). Morphological damage was detected using neurofilament immunohistochemistry (SMI 32… CONTINUE READING
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