Dynamic simulation of the mouse prion protein.

  title={Dynamic simulation of the mouse prion protein.},
  author={Christophe Guilbert and Florence Ricard and Jeremy C. Smith},
  volume={54 6},
Conformational flexibility in the prion protein is believed to play a role in prion diseases. Here we examine the dynamic structure of the mouse cellular prion protein using two one-nanosecond molecular dynamics simulations from different initial conditions. The two simulations produce similar results. The overall structure remains close to that determined by nmr spectroscopy, with small deviations arising from loop fluctuation and slight changes in the relative helix positions. The sequence… CONTINUE READING

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