Dynamic signaling by T follicular helper cells during germinal center B cell selection

@article{Shulman2014DynamicSB,
  title={Dynamic signaling by T follicular helper cells during germinal center B cell selection},
  author={Ziv Shulman and Alexander D. Gitlin and Jason S. Weinstein and Bego{\~n}a Lainez and Enric Esplugues and Richard A Flavell and Joseph E Craft and Michel C. Nussenzweig},
  journal={Science},
  year={2014},
  volume={345},
  pages={1058-1062}
}
T follicular helper (TFH) cells select high-affinity, antibody-producing B cells for clonal expansion in germinal centers (GCs), but the nature of their interaction is not well defined. Using intravital imaging, we found that selection is mediated by large but transient contacts between TFH and GC B cells presenting the highest levels of cognate peptide bound to major histocompatibility complex II. These interactions elicited transient and sustained increases in TFH intracellular free calcium… CONTINUE READING
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