Dynamic selection of novel vancomycin N-terminal derivatives by resin-bound reversed D-Ala-D-Ala.

@article{Chen2008DynamicSO,
  title={Dynamic selection of novel vancomycin N-terminal derivatives by resin-bound reversed D-Ala-D-Ala.},
  author={Yu-Yan Chen and Wen-yi He and Yan Hua Wu and Chang-qun Niu and G. F. Liu},
  journal={Journal of combinatorial chemistry},
  year={2008},
  volume={10 6},
  pages={
          914-22
        }
}
The most attractive advantage of dynamic combinatorial chemistry (DCC) is that it can screen the compound library as soon as compounds are synthesized. However, it is very difficult to analyze a dynamic combinatorial library with free probes using the state-of-the art analysis technologies. We report herein a method that uses a resin-immobilizing reversed peptide probe to screen vancomycin derivatives and provides a solution to this problem. 

Topics from this paper.