Dynamic roles of ion currents in early development
@article{Tosti2010DynamicRO, title={Dynamic roles of ion currents in early development}, author={Elisabetta Tosti}, journal={Molecular Reproduction and Development}, year={2010}, volume={77} }
Excitable cells have the capacity to modify their electrical properties in response to different stimuli. This specific feature is due to a flux of ion currents that flow via ion channels in the plasma membrane. In all species so far studied, ion channels are proteins expressed in the zygote and in the blastomeres of the developing embryo, and their activity is subject to dynamic changes throughout the early cleavage stages. Although these complex patterns imply that ion currents play a role in…
19 Citations
Ion currents in embryo development.
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This review describes the involvement of ion currents in early embryo development, from marine invertebrates to human, focusing on the occurrence, modulation, and dynamic role of ion fluxes taking place on the zygote and blastomere plasma membrane, and at the intercellular communication between embryo cell stages.
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The results summarized here point to the possible functional role of ion channels underlying oocyte growth and maturation in species from invertebrates to mammals.
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- BiologyAdvances in experimental medicine and biology
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The critical role of calcium oscillations in the process of oocyte activation is discussed, the role of PLCs in this fundamental biological reaction is reviewed, and how PLCζ has been formally linked to male infertility is described.
Transmembrane H+ fluxes and the regulation of neural induction in Xenopus laevis.
- BiologyZygote
- 2021
In vivo data corroborated and extended the earlier explant-derived report describing changes in pHi that were suggested to play a role during neural induction in X. laevis embryos, and confirmed the presence of the early neural gene, Zic3, in treated embryos compared with the solvent controls.
Acid stress mediated adaptive divergence in ion channel function during embryogenesis in Rana arvalis
- BiologyScientific reports
- 2015
It is found that ion channels that mediate Ca2+ influx are essential for embryonic survival under acidic pH, and, intriguingly, that populations differ in calcium channel function.
Roles of Src family kinase signaling during fertilization and the first cell cycle in the marine protostome worm Cerebratulus.
- BiologyThe International journal of developmental biology
- 2010
Findings fail to support the view that SFKs are required for initiating fertilization-induced calcium oscillations in Cerebratulus, and alternative mechanisms for the observed inhibition of polar body formation and cleavage in drug-treated specimens are discussed.
Stage specific proteome signatures in bovine oocyte maturation and early embryogenesis
- Biology
- 2015
This thesis addresses early mammalian development, i.e., oocyte maturation and the first steps of embryogenesis, by holistic iTRAQ-based discovery approaches and by a targeted approach based on SRM, a highly sensitive tool for detection of disturbances and disorders of embryonic development at the molecular level.
Could modifications of signalling pathways activated after ICSI induce a potential risk of epigenetic defects?
- BiologyThe International journal of developmental biology
- 2011
The hypothesis that potential perturbations during the ICSI procedure may have repercussions on epigenetic processes, inducing not only alterations of embryonic development, but also diseases in young children and, perhaps, in adults is discussed.
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