Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylInositol 3-kinase inhibition.

@article{Prez2005DynamicRO,
  title={Dynamic reorganization of the astrocyte actin cytoskeleton elicited by cAMP and PACAP: a role for phosphatidylInositol 3-kinase inhibition.},
  author={Virgili P{\'e}rez and Tristan Bouschet and C{\'e}line Fernandez and J{\"o}el Bockaert and Laurent Journot},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 1},
  pages={26-32}
}
Cyclic AMP (cAMP)-raising agents induce astrocytes grown in vitro to adopt a stellate morphology resembling their in vivo appearance, through the depolymerization of actomyosin stress fibres. The signalling pathways responsible for cAMP-induced astrocyte stellation have thus far remained largely elusive. We showed in this study that the neurotrophic peptide PACAP (pituitary adenylate cyclase-activating polypeptide) mimicked the effect of forskolin, a direct activator of adenylate cyclase, on… CONTINUE READING
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