Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence.

@article{Grigoryev2004DynamicRO,
  title={Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence.},
  author={Sergei A Grigoryev and Tatiana Nikitina and John R. Pehrson and Prim B. Singh and Christopher L. F. Woodcock},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 25},
  pages={6153-62}
}
Quiescent lymphocytes have small nuclei, filled with masses of facultative heterochromatin. Upon receiving mitogenic signals, these cells undergo nuclear enlargement, chromatin decondensation, the reactivation of cell proliferation, and changes in the intranuclear positioning of key genes. We examined the levels and intranuclear localization of major histone modifications and non-histone heterochromatin proteins in quiescent and reactivated mouse spleen lymphocytes. Dramatic and selective… CONTINUE READING
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Chromatin remodeling during terminal maturation of mouse erythroid cells

  • E. Popova, S. Grigoryev, M. Koury, J. A. Chasis, S. W. Krauss
  • Curr . Biol .
  • 2003
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