Dynamic regulatory interactions of rad51, rad52, and replication protein-a in recombination intermediates.

@article{Sugiyama2009DynamicRI,
  title={Dynamic regulatory interactions of rad51, rad52, and replication protein-a in recombination intermediates.},
  author={Tomohiko Sugiyama and Noriko Kantake},
  journal={Journal of molecular biology},
  year={2009},
  volume={390 1},
  pages={45-55}
}
Rad51, Rad52, and replication protein-A (RPA) play crucial roles in the repair of DNA double-strand breaks in Saccharomyces cerevisiae. Rad51 mediates DNA strand exchange, a key reaction in DNA recombination. Rad52 recruits Rad51 into single-stranded DNAs (ssDNAs) that are saturated with RPA. Rad52 also promotes annealing of ssDNA strands that are complexed with RPA. Specific protein-protein interactions are involved in these reactions. Here we report new biochemical characteristics of these… CONTINUE READING