Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans.

@article{Liu2002DynamicRO,
  title={Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans.},
  author={Dongfang Liu and Zachary H. Shriver and Yiwei Qi and Ganesh Venkataraman and Ram Sasisekharan},
  journal={Seminars in thrombosis and hemostasis},
  year={2002},
  volume={28 1},
  pages={67-78}
}
This article focuses on the emerging views and concepts concerning the role of cell surface and extracellular heparan sulfate-like glycosaminoglycans (HSGAGs) in tumor biology. HSGAGs, found ubiquitously both at the cell surface and in the extracellular matrix (ECM), play a critical role in regulating tumor initiation, progression, and metastasis. The diverse biological functions of HSGAGs include the regulation of coagulation, growth factor signaling, cell adhesion, proliferation, and mobility… CONTINUE READING

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