Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation.

@article{Mohapatra2007DynamicRO,
  title={Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation.},
  author={Durga P. Mohapatra and K.-S. Park and James S. Trimmer},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 5},
  pages={
          1064-8
        }
}
Voltage-gated K(+) channels are key regulators of neuronal excitability. The Kv2.1 voltage-gated K(+) channel is the major delayed rectifier K(+) channel expressed in most central neurons, where it exists as a highly phosphorylated protein. Kv2.1 plays a critical role in homoeostatic regulation of intrinsic neuronal excitability through its activity- and calcineurin-dependent dephosphorylation. Here, we review studies leading to the identification and functional characterization of in vivo Kv2… 
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