Dynamic regulation of the endocannabinoid system: implications for analgesia

@article{Sagar2009DynamicRO,
  title={Dynamic regulation of the endocannabinoid system: implications for analgesia},
  author={Devi Rani Sagar and A Gemma Gaw and Bright N Okine and Stephen G. Woodhams and Amy Wong and David A. Kendall and V. Chapman},
  journal={Molecular Pain},
  year={2009},
  volume={5},
  pages={59 - 59}
}
The analgesic effects of cannabinoids are well documented, but these are often limited by psychoactive side-effects. Recent studies indicate that the endocannabinoid system is dynamic and altered under different pathological conditions, including pain states. Changes in this receptor system include altered expression of receptors, differential synthetic pathways for endocannabinoids are expressed by various cell types, multiple pathways of catabolism and the generation of biologically active… CONTINUE READING
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