Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression.

Abstract

Although the PR-Set7/Set8/KMT5a histone H4 Lys 20 monomethyltransferase (H4K20me1) plays an essential role in mammalian cell cycle progression, especially during G2/M, it remained unknown how PR-Set7 itself was regulated. In this study, we discovered the mechanisms that govern the dynamic regulation of PR-Set7 during mitosis, and that perturbation of these… (More)
DOI: 10.1101/gad.1984210

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