Dynamic regulation of sodium/calcium exchange function in human heart failure.

  title={Dynamic regulation of sodium/calcium exchange function in human heart failure.},
  author={Christopher R. Weber and Valentino Piacentino and Steven R. Houser and Donald M. Bers},
  volume={108 18},
BACKGROUND Sarcolemmal Na/Ca exchange (NCX) regulates cardiac Ca and contractility. NCX function during the cardiac cycle is determined by intracellular [Ca] and [Na] ([Ca]i, and [Na]i) and membrane potential (Em), which all change in human heart failure (HF). Therefore, changes in NCX function may contribute to abnormal Ca regulation in human HF. METHODS AND RESULTS We assessed the cellular bases of differences in NCX function in ventricular myocytes from failing (F) and nonfailing (NF… CONTINUE READING

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